Not generally. Shipments going to your business whether that address is an actual business location or a residence will ship with no signature required. If the FedEx driver cannot deliver a package to someone at the address and he/she determines it is not safe or practical to leave a package unattended, he/she may leave a door tag for the recipient letting them know the delivery will be attempted again, or that the recipient may contact FedEx and arrange to pick up the package at a FedEx facility.